Nicholas Topley Selected Research

Icodextrin (Extraneal)

10/2018	Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport.
7/2017	miR-21 Promotes Fibrogenesis in Peritoneal Dialysis.
11/2014	The use of exchange-free periods alternating with daily exchanges of icodextrin in the initial treatment of peritoneal dialysis-associated peritonitis: a safety study.
1/2012	Intraperitoneal IL-6 signaling in incident patients treated with icodextrin and glucose bicarbonate/lactate-based peritoneal dialysis solutions.

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Nicholas Topley Research Topics

Disease

24	Inflammation (Inflammations) 01/2019 - 08/2003
22	Peritonitis 01/2020 - 11/2002
13	Infections 01/2017 - 11/2002
7	Fibrosis (Cirrhosis) 01/2018 - 05/2004
5	Peritoneal Fibrosis 10/2018 - 03/2016
5	Arthritis (Polyarthritis) 01/2010 - 09/2003
4	Wounds and Injuries (Trauma) 03/2006 - 08/2002
3	Bacterial Infections (Bacterial Infection) 12/2013 - 09/2005
2	Neoplasms (Cancer) 10/2017 - 07/2004
2	Chronic Kidney Failure (Chronic Renal Failure) 07/2017 - 01/2016
2	Experimental Arthritis 07/2007 - 09/2003
2	Rheumatoid Arthritis 07/2007 - 05/2006
1	Urinary Tract Infections (Urinary Tract Infection) 12/2019
1	Left Ventricular Dysfunction 01/2019
1	Heart Diseases (Heart Disease) 01/2019
1	Necrosis 03/2016
1	Reinfection 01/2016
1	Albuminuria 03/2015
1	Renal Insufficiency (Renal Failure) 12/2013
1	Acute Disease 07/2013
1	Sepsis (Septicemia) 05/2013
1	Hematuria 01/2010
1	Kidney Diseases (Kidney Disease) 01/2010
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2010
1	Lupus Nephritis 01/2010
1	Proteinuria 01/2010
1	Pneumonia (Pneumonitis) 08/2009
1	Multiple Abnormalities 11/2008
1	Disease Progression 08/2008

Drug/Important Bio-Agent (IBA)

18	Interleukin-6 (Interleukin 6)IBA 01/2020 - 08/2003
10	CytokinesIBA 01/2018 - 08/2003
7	Dialysis SolutionsIBA 01/2019 - 05/2003
7	SolutionsIBA 10/2018 - 07/2004
6	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2016
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 08/2003
5	ChemokinesIBA 05/2011 - 05/2004
4	Glucose (Dextrose)FDA LinkGeneric 10/2018 - 01/2012
4	Icodextrin (Extraneal)FDA Link 10/2018 - 01/2012
4	Peptides (Polypeptides)IBA 05/2013 - 01/2003
4	AntigensIBA 01/2010 - 07/2004
3	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2018 - 05/2013
3	Hyaluronic Acid (Hyaluronan)IBA 01/2018 - 05/2004
3	LigandsIBA 01/2018 - 12/2011
3	Interleukin-8 (Interleukin 8)IBA 10/2017 - 08/2002
3	InterferonsIBA 03/2016 - 01/2014
3	Matrix Metalloproteinases (MMPs)IBA 01/2016 - 01/2010
3	4-hydroxy-3-methylbut-2-enyl pyrophosphateIBA 07/2013 - 02/2009
3	Cytokine Receptor gp130IBA 01/2012 - 09/2003
3	Protein Isoforms (Isoforms)IBA 01/2010 - 05/2004
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2019 - 12/2013
2	MicroRNAs (MicroRNA)IBA 10/2017 - 07/2017
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2017 - 07/2004
2	Complement System Proteins (Complement)IBA 01/2017 - 09/2011
2	Guanosine Diphosphate (GDP)IBA 01/2016 - 01/2014
2	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2012 - 09/2003
2	EicosanoidsIBA 02/2011 - 08/2009
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2010 - 02/2005
2	Interleukin-1beta (Interleukin 1 beta)IBA 01/2010 - 07/2007
2	Interferon-gamma (Interferon, gamma)IBA 01/2010 - 07/2007
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2010 - 02/2005
2	Oncostatin MIBA 08/2008 - 11/2002
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2007 - 07/2004
2	Transforming Growth Factors (Transforming Growth Factor)IBA 08/2005 - 04/2005
1	Matrix Metalloproteinase 8 (Neutrophil Collagenase)IBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	Serum AlbuminIBA 01/2019
1	Toll-Like Receptor 2IBA 01/2018
1	Advanced Oxidation Protein Products (AOPP)IBA 10/2017
1	Interleukin-17 (Interleukin 17)IBA 10/2017
1	Anaphylatoxin C5a ReceptorIBA 01/2017
1	Tissue Inhibitor of Metalloproteinase-1IBA 01/2016
1	insulin receptor-related receptor (IRR)IBA 01/2016
1	Interleukin-10 (Interleukin 10)IBA 01/2016
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/2016
1	4-hydroxy-3-methyl-2-butenyl diphosphateIBA 01/2016
1	Riboflavin (Vitamin B2)FDA LinkGeneric 01/2016
1	Trefoil Factor-3IBA 03/2015
1	ClusterinIBA 03/2015
1	STAT1 Transcription FactorIBA 01/2014
1	Bicarbonates (Hydrogen Carbonate)IBA 01/2012
1	CreatinineIBA 01/2012
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2012
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 02/2011
1	Mitogen-Activated Protein KinasesIBA 02/2011
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 02/2011
1	Phospholipases (Phospholipase)IBA 02/2011
1	Phosphotransferases (Kinase)IBA 02/2011
1	Type C PhospholipasesIBA 02/2011
1	phosphatidylethanolamineIBA 08/2009
1	Interleukin-4 (Interleukin 4)IBA 08/2009
1	LipidsIBA 08/2009
1	Interleukin-13IBA 08/2009
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2008
1	Oncostatin M Receptor beta SubunitIBA 08/2008
1	NF-kappa B (NF-kB)IBA 08/2008
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 05/2006

Therapy/Procedure

26	Peritoneal Dialysis 01/2020 - 05/2003
2	Catheters 01/2018 - 01/2017
1	Therapeutics 07/2017
1	Renal Replacement Therapy (Therapies, Renal Replacement) 07/2017